An  American phase 2 study reported in 2008. 25 patients had curcumin treatment and 21 had tumours that could be measured. In 2 patients their tumours shrank or remained stable. In some patients their levels of particular immune system chemicals that destroy cancer cells went up. But the researchers found that blood levels of curcumin were very low because it is not well absorbed from the gut. Scientists have since developed injectable, fat soluble forms of curcumin which may improve the results.


According to Dariush Mozaffarian at Tufts, it’s not just excessive fructose, alcohol, trans fats, and BCAAs however. Both starch and sugars, in rapidly digested and high dose forms (aka the “refined carbs” as found in processed foods), are leading causes of NAFLD and metabolic syndrome. While fructose goes directly to de novo lipogenesis (DNL), glucose does as well when quickly digested in larger doses (starch or sugar)! So look at overall starch and sugar injestion, not fructose per se. A baked potato is essentially 100% glucose - avoid. Small amounts of potato mixed in with veggies, plant oils, etc. are better, but still best to just avoid - so many other fruits and nonstarchy veggies to eat. For carb-rich foods: 1) think of them as small sides, never the main part of the plate, and 2) look at the ratio of carb to fiber as a good general rule. Look for <10:1 ratio: no more than 10 g of total carb for every 1 g of fiber; the lower the better.


My only worry is that it raises free testosterone. Many women today are having reproductive issues (mainly PCOS, which already raises free testosterone levels and causes a world of problems). I wonder if this would raise the number of PCOS cases or cause more issues in women with hormonal imbalances. I really look forward to seeing more studies in this because it is so difficult to lose weight with these issues.

A 2014 Harvard study found that men who did twenty minutes of daily weight training had less of an increase in age-related abdominal fat compared with men who spent the same amount of time doing aerobic activities, and other studies have shown similar levels of success when guys hit the gym to cut down on fat. The implication: Guys can cut belly fat most efficiently with weight training.

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A diet that’s low in fat and carbohydrates can improve artery function, according to a 2012 study by Johns Hopkins researchers. After six months, those on the low-carb diet had lost more weight, and at a faster pace. But in both groups, when weight was lost—and especially when belly fat shrank—the arteries were able to expand better, allowing blood to travel more freely. The study shows that you don’t have to cut out all dietary fat to shrink belly fat. For heart health, simply losing weight and exercising seems to be key. 
When the authors of the new report reviewed 35 previous studies of turmeric supplements in people, they found that about 5 percent of participants in those studies experienced liver problems tied to the supplements. It may be that some patients, such as older adults or those who consume alcohol, are more prone to these problems tied to supplements.
An  American phase 2 study reported in 2008. 25 patients had curcumin treatment and 21 had tumours that could be measured. In 2 patients their tumours shrank or remained stable. In some patients their levels of particular immune system chemicals that destroy cancer cells went up. But the researchers found that blood levels of curcumin were very low because it is not well absorbed from the gut. Scientists have since developed injectable, fat soluble forms of curcumin which may improve the results.
The most important thing to know is that “stubborn fat” in both men and women is stubborn for a reason: it is structurally different than regular fat because it has more alpha-2 receptors (which inhibit fat loss) than beta-2 receptors (which enable fat loss). This is why when you lose fat, you lose it everywhere except where you really want to lose it!
Curcumin works with the gallbladder, stimulating it to make bile, which may help with digestion. In Germany, turmeric can be prescribed for digestive problems. Some research shows that turmeric may help upset stomach, bloating and gas. Turmeric may also help reduce the occurrence of irritable bowel syndrome (IBS) in people who are otherwise healthy.
My only worry is that it raises free testosterone. Many women today are having reproductive issues (mainly PCOS, which already raises free testosterone levels and causes a world of problems). I wonder if this would raise the number of PCOS cases or cause more issues in women with hormonal imbalances. I really look forward to seeing more studies in this because it is so difficult to lose weight with these issues.
Despite the diagnosis, doctors weren’t sure what was causing autoimmune hepatitis in the woman. For three months she was monitored closely but did not receive a specific treatment. She then told her doctor she stopped taking the turmeric supplements because she read online that they could be linked to liver problems. She hadn’t mentioned to her doctors that she was taking the supplements before that point.
Arteries (are-te-rease): The blood vessels that carry oxygen-rich blood away from your heart for delivery to every part of your body. Arteries look like thin tubes or hoses. The walls are made of a tough outer layer, a middle layer of muscle and a smooth inner wall that helps blood flow easily. The muscle layer expands and contracts to help blood move.

Because curcumin crosses the blood-brain barrier, research has suggested the brain can also benefit from its anti-inflammatory, antioxidant benefits and stave off conditions like Alzheimer’s. Use turmeric in an all-purpose spice blend for fish or to toss with olive oil and toast up with walnuts, another food shown to protect brain function as we age. 

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Forskolin is an herbal extract from Coleus forskohlii, a plant belonging to the mint family. Its mechanism of action? It increases the production of cyclic AMP, which increases the contractility of heart muscle. Evidence for other actions is preliminary and inconclusive: there is speculation that it may have effects in other cells of the body such as platelet and thyroid cells, it may prevent platelet aggregation and adhesions, and it might even prevent tumor cell growth and cancer metastasis. So far, there is no evidence that it is clinically useful or safe for those purposes.

Turmeric is a perennial plant that is cultivated throughout Southeast Asia, China, Australia, and the South Pacific. The plant grows to a height of 0.9 to 1.5 m and bears large, oblong leaves and funnel-shaped, dull-yellow flowers. The thick rhizome is yellowish on the outside and deep orange or reddish brown inside. The lateral rhizomes contain more yellow coloring than the bulb. The dried primary bulb and secondary lateral rhizomes are collected, cleaned, boiled, and dried for use in medicinal and food preparations.
In 2009, Biochemistry and Biophysical Research Communications published a lab study out of Auburn University that explored the potential of curcuminoids to lower glucose levels. The study discovered that curcumin in turmeric is literally 400 times more potent than metformin (a common diabetes drug) in activating the enzyme AMPK (AMP-activated protein kinase). One compound produced by fermentation of curcumin, tetrahydrocurcumin, activated AMPK up to 100,000 times more than metformin in certain cells! (38)
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Shekelle, P. G., Hardy, M. L., Morton, S. C., Maglione, M., Mojica, W. A., Booth, M. S., … Gagné, J. (2003, March 26). Efficacy and safety of ephedra and ephedrine for weight loss and athletic performance: A meta-analysis. JAMA, 289(12), 1537-1545. Retrieved from https://www.researchgate.net/publication/236281601_Efficacy_and_Safety_of_Ephedra_and_Ephedrine_for_Weight_Loss_and_Athletic_PerformanceA_Meta-analysis
Like many supplements that are commonly used for weight loss, there are many disreputable companies selling what they claim to be forskolin extract that are dangerous and contain unnamed ingredients. If you buy forskolin, I recommend pure forskolin. For safety reasons, it’s important to only purchase supplements from trusted companies, follow dosing instructions carefully and take these supplements under the supervision of your doctor.
The supplement is also named after the desired compound in this herb that achieves the fat-burning effects: forskolin (also called “coleonol”), a labdane diterpene unique to Indian Coleus only. Labdane diterpenes are found in many other plants, but what makes the ones from Indian Coleus so exciting is their unique, impressive effects: found in no other plant in the world. (1)
Hanai, H., Iida, T., Takeuchi, K., Watanabe, F., Maruyama, Y., Andoh, A., Tsujikawa, T., Fujiyama, Y., Mitsuyama, K., Sata, M., Yamada, M., Iwaoka, Y., Kanke, K., Hiraishi, H., Hirayama, K., Arai, H., Yoshii, S., Uchijima, M., Nagata, T., and Koide, Y. Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial. Clin Gastroenterol.Hepatol. 2006;4(12):1502-1506. View abstract.

Forskolin (coleonol) is a labdane diterpene that is produced by the Indian Coleus plant (Plectranthus barbatus). Other names include pashanabhedi, Indian coleus, makandi, HL-362, NKH477, and mao hou qiao rui hua.[2] As with other members of the large diterpene family of natural products, forskolin is derived from geranylgeranyl pyrophosphate (GGPP). Forskolin contains some unique functional elements, including the presence of a tetrahydropyran-derived heterocyclic ring. Forskolin is a commonly used material in laboratory research to increase levels of cyclic AMP by stimulation of adenylate cyclase.[2]
After she stopped taking the supplements, the woman’s liver enzymes decreased rapidly. The researchers reported that 10 to 15 percent of autoimmune hepatitis cases are from drugs or supplements. After analyzing 35 studies that looked into turmeric supplements in people, they discovered that 5 percent of participants developed liver problems because of the supplements. People who drink alcohol or are older may be more likely to develop a liver problem.

The details of the study are not important. What’s important is that the subjects taking forskolin did not lose weight. Even without weight loss, the changes in body composition are likely beneficial, but the increase in testosterone could be dangerous. Whatever the unresolved questions about benefits and risks, it is obviously misleading to cite this study as evidence that forskolin has been proven to melt belly fat or improve weight loss.
In the UK, up to 5% of the general population is underweight, but more than 10% of those with lung or gastrointestinal diseases and who have recently had surgery.[29] According to data in the UK using the Malnutrition Universal Screening Tool ('MUST'), which incorporates unintentional weight loss, more than 10% of the population over the age of 65 is at risk of malnutrition.[29] A high proportion (10-60%) of hospital patients are also at risk, along with a similar proportion in care homes.[29]
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The details of the study are not important. What’s important is that the subjects taking forskolin did not lose weight. Even without weight loss, the changes in body composition are likely beneficial, but the increase in testosterone could be dangerous. Whatever the unresolved questions about benefits and risks, it is obviously misleading to cite this study as evidence that forskolin has been proven to melt belly fat or improve weight loss.
i was given this as a gift by a family member and was a bit skeptical at first. I had tried other products in the past that were similar and never worked very well for me. Within a week of taking this product everyday, I was noticing that my sleep was more restful, and that I was waking up a lot less during the night. Within a month of following the treatment regimen, I had actually started to slim down a bit. I wasn't dropping tens of pounds a week but that would have been pretty unrealistic. After 2 months I was at my ideal body weight and was blown away by how well this product worked. I was only looking to slim down 6-7 lbs and this did it for me. Will definitely purchase again if i ever need to slim down again haha

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Lee, J. C., Kinniry, P. A., Arguiri, E., Serota, M., Kanterakis, S., Chatterjee, S., Solomides, C. C., Javvadi, P., Koumenis, C., Cengel, K. A., and Christofidou-Solomidou, M. Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice. Radiat.Res 2010;173(5):590-601. View abstract.
Asthma, a condition in which airways become inflamed and swollen, is another condition historically treated by forskolin. It turns out that these benefits are very real indeed. Traditionally, asthma is treated by steroidal inhalers or cromoglicic acid, a non-steroidal inhaler, as well as various anti-inflammatory drugs and bronchodilators — the latter of which is used for emergency treatment to open airways during an asthma attack.

In Robert Lustig’s commentary, “Sickeningly Sweet: Does Sugar Cause Type 2 Diabetes? Yes” (Can J Diabetes 40 (2016) 282–286), when BCAAs are provided in excess beyond anabolic requirements, these classic ketogenic amino acids must be deaminated in the liver to be diverted toward energy utilization. This supplies too much acetyl-CoA to liver mitochondria, leading to liver-fat formation, and BCAA serum concentrations correlate with metabolic syndrome. Therefore, it is wise to limit BCAA consumption to pre- and post-workout drinks if doing fasted workouts. I simply stopped using BCAAs entirely as they provide zero benefits (Mike Matthews has a great podcast on this).


Though we often associate turmeric with spicy foods, it has actually been used to treat inflammatory bowel conditions like colitis. Try it in a gut-soothing soup using organic chicken bone broth as the base. Turmeric also happens to be a low-FODMAP food, so it's safe to use if you’re on a FODMAPs elimination diet. It pairs well with pureed kabocha or pumpkin, which are also low-FODMAP.
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