Shekelle, P. G., Hardy, M. L., Morton, S. C., Maglione, M., Mojica, W. A., Booth, M. S., … Gagné, J. (2003, March 26). Efficacy and safety of ephedra and ephedrine for weight loss and athletic performance: A meta-analysis. JAMA, 289(12), 1537-1545. Retrieved from https://www.researchgate.net/publication/236281601_Efficacy_and_Safety_of_Ephedra_and_Ephedrine_for_Weight_Loss_and_Athletic_PerformanceA_Meta-analysis
Forskolin (coleonol) is a labdane diterpene that is produced by the Indian Coleus plant (Plectranthus barbatus). Other names include pashanabhedi, Indian coleus, makandi, HL-362, NKH477, and mao hou qiao rui hua. As with other members of the large diterpene family of natural products, forskolin is derived from geranylgeranyl pyrophosphate (GGPP). Forskolin contains some unique functional elements, including the presence of a tetrahydropyran-derived heterocyclic ring. Forskolin is a commonly used material in laboratory research to increase levels of cyclic AMP by stimulation of adenylate cyclase.
The more you have to lose (obese / extremely overweight), the more you will lose as your body has more fat to spare. Sure, changes to your diet and activity levels will be the base but the magic lies in the details. Most people weight loss journey is mostly about losing a lot of water (and water weight), going on holiday and then coming back home feeling fat and full of guilt. The truth is, fat has nothing to do with it, because they haven’t lost much of it in the first place.