In Robert Lustig’s commentary, “Sickeningly Sweet: Does Sugar Cause Type 2 Diabetes? Yes” (Can J Diabetes 40 (2016) 282–286), when BCAAs are provided in excess beyond anabolic requirements, these classic ketogenic amino acids must be deaminated in the liver to be diverted toward energy utilization. This supplies too much acetyl-CoA to liver mitochondria, leading to liver-fat formation, and BCAA serum concentrations correlate with metabolic syndrome. Therefore, it is wise to limit BCAA consumption to pre- and post-workout drinks if doing fasted workouts. I simply stopped using BCAAs entirely as they provide zero benefits (Mike Matthews has a great podcast on this).
If you have been around for a while, you might not be too surprised to find out that mainstream programs overlook inconvenient yet important parts of the weight loss equation. Not many in the industry like to tackle real problems such as restricted circulation (especially to areas where fat is stubborn, this is no coincidence) or the fact that you must take FFAs out of fat cells (via lipolysis) before attempting to oxidize them (burn fat).
Additional research may back up these findings. One small study looked at participants who were given an identical meal one week apart with the only difference being the timing of the meal (one in the morning and one in the evening). Again, the morning eaters came out ahead with improvements in blood glucose levels and a slight boost in metabolic rate.
Herbal product manufacturers are now producing Coleus forskohlii extracts that contain high levels of forskolin. These preparations are being promoted for the same conditions for which forskolin has been traditionally used. However, currently there is no reliable scientific information that shows Coleus forskohlii extracts taken by mouth are effective.
During the surgery doctors removed liver tissue and they then then measured the levels of curcumin in the tissue. The results showed that the level of curcumin absorbed into the liver was not high enough to have any anticancer effect. The researchers suggested that future clinical trials of curcumin should focus on preventing bowel tumours. Several studies have shown that curcumin taken as capsules does get absorbed by the gut and is present in the blood. But the amount in the blood is small. <