Isn’t it exciting to hear about a weight loss supplement that can simply melt away fat and leave muscle mass unaffected? The answer is, of course, “yes.” However, your follow-up question should then be, “Does it really work?” And the answer to that question is rarely as positive as the initial assertions may sound. This is no different in the case of forskolin, a compound found in a plant in the mint family.
The anti-inflammatory benefits of curcumin may help ease joint pain. Studies have actually shown promising results in the ability of turmeric and curcumin to manage pain and inflammation associated with arthritis. It may also be helpful for athletes looking to soothe soreness. I recommend a smoothie packed with anti-inflammatory, soothing superfoods to my clients struggling with aches and pains. My go-to combo is frozen wild blueberries, roasted or steamed beets (another potent antioxidant-rich food), and turmeric. If you want to make it a meal, add your favorite plant protein.
In 2009, Biochemistry and Biophysical Research Communications published a lab study out of Auburn University that explored the potential of curcuminoids to lower glucose levels. The study discovered that curcumin in turmeric is literally 400 times more potent than metformin (a common diabetes drug) in activating the enzyme AMPK (AMP-activated protein kinase). One compound produced by fermentation of curcumin, tetrahydrocurcumin, activated AMPK up to 100,000 times more than metformin in certain cells! (38)
Do NOT over do it. You cannot rush the process of fat loss. Don’t do more than 1 hr/day of weightlifting and no more than 3X/week and generally fewer than 50 reps per workout. Don’t do more than 3 hours of cardio per week. Don’t cut your calories by more than 25%. Do not fast for more than 18 hours. You may “think” you are going to get results faster, but it always works against you. Your body is really good at taking defensive measures when it thinks it is threatened and you can actually gain weight in a severe deficit. Take everything slow and steady. Ironically, the slow approach is the fastest way to get it done. Heard of “The biggest loser” TV show? By taking a fast approach to weight loss, they truly were the biggest losers in the end. Six years later, they’ve not only regained their weight, but now they have also perhaps permanently lost the ability to lose weight.
It's known that in about 10 to 15 percent of people with autoimmune hepatitis, the condition is triggered by drugs or supplements, the report said. In these cases, the condition is called drug-induced autoimmune hepatitis. It's unclear how drugs or supplements trigger drug-induced autoimmune hepatitis, but it's thought that in some cases, the breakdown of drugs may lead to the formation of molecules that trigger an immune reaction, according to the NIH.
It’s ~possible~ that forskolin may help you lose weight, says Fatima Cody Stanford, M.D., M.P.H., an obesity medicine physician at Massachusetts General Hospital. But—and this is a big but—there's not much in the way of evidence that says it will. “When we have minimal data and experience, I always tell patients to be cautious because we have very few examples to demonstrate not only the utility, but also the safety profile,” she says.
In Robert Lustig’s commentary, “Sickeningly Sweet: Does Sugar Cause Type 2 Diabetes? Yes” (Can J Diabetes 40 (2016) 282–286), when BCAAs are provided in excess beyond anabolic requirements, these classic ketogenic amino acids must be deaminated in the liver to be diverted toward energy utilization. This supplies too much acetyl-CoA to liver mitochondria, leading to liver-fat formation, and BCAA serum concentrations correlate with metabolic syndrome. Therefore, it is wise to limit BCAA consumption to pre- and post-workout drinks if doing fasted workouts. I simply stopped using BCAAs entirely as they provide zero benefits (Mike Matthews has a great podcast on this).
During the surgery doctors removed liver tissue and they then then measured the levels of curcumin in the tissue. The results showed that the level of curcumin absorbed into the liver was not high enough to have any anticancer effect. The researchers suggested that future clinical trials of curcumin should focus on preventing bowel tumours. Several studies have shown that curcumin taken as capsules does get absorbed by the gut and is present in the blood. But the amount in the blood is small. <